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In November 2018, the Food and Drug Administration (FDA) released a statement claiming efforts to reduce animal testing through a study aimed at eliminating the use of dogs in certain animal drug trials.

Cystic fibrosis (CF) is a debilitating genetic disease caused by a mutation that disables essential proteins, resulting in thick mucus forming in the lungs, pancreas, and other organs. For patients, this results in a lifetime difficulty breathing and digestive problems. Tragically, the condition often limits the patient to a 40- or 50-year lifespan.

It’s a disturbing fact that in the U.S. alone, an estimated one million animals are used each year for the development and safety testing of medical devices, a growing multi-billion industry. Yet, an overwhelming 92% of tests that prove safe in animals fail in subsequent human clinical trials.

Mark M. Davis, PhD, has devoted his career to understanding the immune system and its link to disease. Now this esteemed Professor of Microbiology and Immunology at Stanford University School of Medicine is issuing a bold call for human immunology research that focuses on studying human patients, as opposed to artificially induced diseases in animals.

CAARE is building a movement to change the conversation about animal experiments, from a “necessary evil” to an outdated, inhumane and irrelevant method that doesn’t efficiently advance human medicine.

We consistently research and distribute information on the many ways in which biomedical research can be carried out effectively without animals. CAARE also speaks up for animals in laboratories through campaigns that highlight how their suffering is totally unwarranted.

The brain is an immensely complicated, essential organ. Understanding its workings is crucial to curing a wide-range of debilitating diseases, including Parkinson’s, Alzheimer’s, and other neurodegenerative diseases.

Yet, despite decades of highly invasive animal experiments, no significant progress has been made to help human patients.

A new joint research study from Johns Hopkins University and the science safety company, Underwriters Laboratories (UL), shows that computers can predict the safety of chemicals better than animal testing, and at much lower cost. The software program called REACHAcross™ uses big data and Artificial Intelligence to analyze tens of thousands of chemicals to evaluate how they might react in the human body.

Since October 2017, CAARE has been exposing sickening experiments on cats and kittens at the State University of New York College of Optometry (SUNY Optometry). In these horrifying experiments, cats are anesthetized and paralyzed while their skulls are surgically removed and electrodes embedded in their brains so scientists can “map” the response of visual neurons.

May 18, 2018

In 2015 CAARE reported on a new collaboration between biotech startup Emulate Inc. and Janssen pharmaceuticals. Their partnership has now produced a milestone when Emulate’s human blood vessel-chip predicted toxicity of an autoimmune drug previously undetected in experiments using animals.

In recent months we’ve seen dramatic new developments towards replacing animals in drug testing. New innovations have resulted in methods to assess cardiotoxicity, an adverse effect that impacts the heart.