CAARE is building a movement to change the conversation about animal experiments, from a “necessary evil” to an outdated, inhumane and irrelevant method that doesn’t efficiently advance human medicine.

We consistently research and distribute information on the many ways in which biomedical research can be carried out effectively without animals. CAARE also speaks up for animals in laboratories through campaigns that highlight how their suffering is totally unwarranted.

We do all this on a very modest budget powered by YOU—your energy, your dollars and your voices. We take no money from CEOs or large corporations, and our tiny staff – most of whom are volunteers – ensures that your contributions go a long way.

However, increased funding will enable us to conduct far more research and campaigns than we currently can with our small team. That’s why I’m pleased to announce that we are offering beautiful digital pet portraits for a $50 contribution to CAARE. Please read more about these charming portraits and how your participation can help CAARE’s work.

And of course, we are always grateful for every donation, large or small, that helps us make sure we have the resources to keep going and even better, escalate our efforts.

For the animals,
Barbara Stagno
President, CAARE 

Beautiful Pet Portraits
for donations of $50 or more

CAARE has partnered with British artist Natasha Sainsbury to offer beautiful digital portraits from your pet’s photo for your donation of $50 or more. These exquisitely detailed portraits create a beautiful rendition and lasting memory of your beloved animal companions.

Organoid production amplified by robots

“Organoids” are a new generation of three-dimensional cell cultures derived from human cells. In recent years, these models have shown superior ability over animal tests to mimic the function of human organs.

Now a team of investigators at University of Washington are using robots to enhance the process by producing organoids in large quantities that can be used for toxicity and drug testing. Working with kidney cells, the robots created 384 testing chambers over 21 days. Additional testing of the organoids confirmed that they accurately emulate human kidney physiology on a complex level, and even revealed a new finding: that the protein myosin plays a role in polycystic kidney disease.

Nonanimal intestinal models
advance disease research

A scientific review carried out by microbiologists and tissue engineers at Arizona State University (ASU) demonstrates how the world of 3D tissue culture models of the human intestine are changing the way we study infectious disease, while providing a pathway for drug and vaccine discovery. The review focused on the human intestine because many pathogens target the mucosal surface lining the intestine as portals of entry for their assault on the body.

Currently we are lacking human relevant tissue models which impacts the ability to study the infectious disease process, resulting in a 90 percent failure rate of drugs in clinical trials after tests in animals. Worse still, we are lacking adequate vaccines for many pathogens responsible for potentially lethal diseases like tuberculosis, AIDS and serious diarrheal disease.

Cheryl Nickerson professor at the ASU Biodesign Center for Immunotherapy, Vaccines and Virotherapy, explains: "By mimicking the structure and function of native tissues in the body, 3-D tissue models are powerful tools that serve as next generation platforms to unveil novel underlying principles of infectious disease, streamline vaccine/therapeutic discovery, predict how humans will respond to vaccines and other therapeutics, and increase likelihood of success in the most expensive part of vaccine development -- human clinical trials. Moreover, the ability to create these models from patient samples offers exciting potential for personalized medicine."

Follow CAARE on Instagram

CAARE is now on Instagram! In addition to Facebook and Twitter, you can now follow us on Instagram to stay up-to-date on our latest news and campaigns. See you there.

Citizens for Alternatives to Animal Research & Experiments (CAARE), is a 501(c)(3) non-profit organization, established to highlight and promote research without animals.

Your donation helps us carry out our mission to speak up for animals in laboratories, and to end animal suffering by disseminating information about the power and progress of research without animals.