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Combatting the world’s deadliest viruses without animal tests

A new study conducted by an international conglomeration of scientists has found that human-based methods are more likely to produce successful results for studying treatments for deadly viruses than experiments on mice or monkeys.

The study, led by Dr. David Pamies at University of Lausanne in Switzerland, focused on a class of viruses known as mosquito-borne flaviviruses (MBF). These viruses are responsible for lethal and devastating diseases like dengue fever and Zika virus, which can cause catastrophic deformities in newborns.

The scholarly report examined human-mimetic approaches that include innovative technologies like induced pluripotent stem cell models, brain-specific organoids, in silico mathematical modeling, and others, all without the use of animals.

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Shop CAARE at CafePress

CAARE is happy to announce the opening of our CafePress store.

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World’s leading genomics institute to close animal lab

In a remarkable sign that support for animal research is declining, the world renowned Wellcome Sanger Institute in the UK recently announced the upcoming closure of its animal research facility.

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Getting life-saving therapeutics to patients faster

At the heart of the wave of new technologies to replace animals in research are the biotech companies utilizing modern scientific methods that are fundamentally human, and not derived from animals.

CAARE recently connected with Dr. Jo Varshney, CEO and founder of VeriSIM Life. She established her company to solve the critical bottleneck in getting life-saving therapeutics from development to patients, a problem that is largely due to poor translatability from animal tests.

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Unlocking the power of human cells to study ALS

Amyotrophic Lateral Sclerosis (ALS) is a tragic, progressive, and fatal disease that causes nerve cells to degenerate, resulting in the gradual loss of muscle control. Increasing weakness eventually disrupts the body’s ability to move, swallow, and even breathe.

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Combating heart disease with lab-grown “hearts-in-a-jar”

Despite the use of innumerable animals in cardiac experiments, cardiotoxicity – damage to the heart – remains the key reason drugs fail in clinical trials.

A growing number of scientists and biotech firms are working to change this by developing lab-grown, miniature beating human hearts. One such company, Novoheart, is pioneering an array of next-generation human heart tissue prototypes.

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Tell the FDA to do more to end animal tests

In November 2018, the Food and Drug Administration (FDA) released a statement claiming efforts to reduce animal testing through a study aimed at eliminating the use of dogs in certain animal drug trials.

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Cystic Fibrosis Research Gets New Boost from Human Lung Models

Cystic fibrosis (CF) is a debilitating genetic disease caused by a mutation that disables essential proteins, resulting in thick mucus forming in the lungs, pancreas, and other organs. For patients, this results in a lifetime difficulty breathing and digestive problems. Tragically, the condition often limits the patient to a 40- or 50-year lifespan.

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Simulated systems replace animals for medical device testing

It’s a disturbing fact that in the U.S. alone, an estimated one million animals are used each year for the development and safety testing of medical devices, a growing multi-billion industry. Yet, an overwhelming 92% of tests that prove safe in animals fail in subsequent human clinical trials.

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Immunology Expert Calls for More Human, Less Animal Research

Mark M. Davis, PhD, has devoted his career to understanding the immune system and its link to disease. Now this esteemed Professor of Microbiology and Immunology at Stanford University School of Medicine is issuing a bold call for human immunology research that focuses on studying human patients, as opposed to artificially induced diseases in animals.

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